Episodes

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A Discussion on Virtual Controls

A Discussion on Virtual Controls

Episode 81 · · 47:28

In this episode of "In the Interim…", Dr. Scott Berry shares the framework he presented at a CSRC regulatory science hackathon on digital twins and synthetic controls in cardiovascul...

Clinical Trial Arenas: Direct Communication to Patients

Clinical Trial Arenas: Direct Communication to Patients

Episode 80 · · 43:02

In this episode of "In the Interim…", Dr. Scott Berry recounts a presentation he gave to the Speak Foundation, a patient organization focused on limb-girdle muscular dystrophy and ma...

Science Coaching With Alun Bedding

Science Coaching With Alun Bedding

Episode 79 · · 45:11

In this episode of "In the Interim…", Dr. Scott Berry talks with Dr. Alun Bedding, a professional certified coach and statistician who spent decades in pharmaceutical statistics, inc...

The CHIPS Trial: Bayesian Adaptive Trial in JAMA

The CHIPS Trial: Bayesian Adaptive Trial in JAMA

Episode 78 · · 45:40

In this episode of “In the Interim…,” Dr. Scott Berry talks with Dr. Roger Lewis, Dr. Anna McGlothlin, and Dr. Nick Berry — all co-authors on the CHIPS trial results recently publish...

NFL Study of CTE: The Issues

NFL Study of CTE: The Issues

Episode 77 · · 38:46

In this episode of "In the Interim…", Dr. Scott Berry examines three recent health-research headlines through a statistician's lens: an Adventist Health Study-2 analysis claiming egg...

Talkin' 'bout Sweet Time

Talkin' 'bout Sweet Time

Episode 76 · · 47:03

In this episode of "In the Interim...", Dr. Scott Berry dissects prevailing concepts of “clinically meaningful difference” in clinical trials focusing on progressive diseases. Throug...

Mammograms: Death Threats, Hillary Clinton and Lead-Time Bias

Mammograms: Death Threats, Hillary Clinton and Lead-Time Bias

Episode 75 · · 01:05:42

In this episode of "In the Interim…", Dr. Don Berry provides a detailed account of co-chairing the 1997 NIH consensus development conference on mammography for women in their 40s. Hi...

REMAP-CAP Results: Oseltamivir in Critically-Ill Influenza Patients

REMAP-CAP Results: Oseltamivir in Critically-Ill Influenza Patients

Episode 74 · · 51:58

In this episode of "In the Interim…", Dr. Scott Berry speaks with Dr. Srinivas Murthy, Dr. Thomas Hills, and Dr. Lindsay Berry about the REMAP-CAP trial results on oseltamivir in cri...

ICECAP: The Results

ICECAP: The Results

Episode 73 · · 54:42

In this episode of "In the Interim…", Dr. Scott Berry leads a comprehensive discussion of the ICECAP trial results with four Principal Investigators: Dr. Will Meurer (Professor, Emer...

Failure of the Proportional Odds is the Result

Failure of the Proportional Odds is the Result

Episode 72 · · 40:20

In this episode of "In the Interim…", Dr. Scott Berry and Dr. Elizabeth Lorenzi systematically examine the analytic pitfalls in recent acute ischemic stroke trials, especially the im...

Adaptive Design Actions Matrix

Adaptive Design Actions Matrix

Episode 71 · · 30:43

In this episode of "In the Interim…", Dr. Scott Berry challenges the widely held belief that any interim look at trial data obligates an alpha adjustment. By constructing a two-by-tw...

A Visit With Tim Berry

A Visit With Tim Berry

Episode 70 · · 44:20

In this episode of "In the Interim…," Dr. Scott Berry interviews Tim Berry, co-founder of Blend360, detailing a career that demonstrates the practical application of statistical and ...

Fairness in Soccer and Clinical Trials

Fairness in Soccer and Clinical Trials

Episode 69 · · 34:33

In this episode of "In the Interim...", Dr. Scott Berry investigates the practical meaning of fairness by connecting a controversial World Cup soccer ruling to foundational questions...

Bias in Stopping Trials Early

Bias in Stopping Trials Early

Episode 68 · · 39:29

On the latest episode of "In the Interim...", Dr. Scott Berry and Dr. Kert Viele deliver a focused, technical analysis of statistical bias when stopping trials early. This episode cl...

A Statistician Reads JAMA: A Futile Issue

A Statistician Reads JAMA: A Futile Issue

Episode 67 · · 46:13

On the latest episode of "In the Interim…", Dr. Scott Berry provides an empirical examination of two recent JAMA trials: TRACK (low-dose rivaroxaban in advanced kidney disease) and V...

Response-Adaptive Randomization in Clinical Trials

Response-Adaptive Randomization in Clinical Trials

Episode 66 · · 47:19

In this episode of "In the Interim…", Dr. Scott Berry and Dr. Kert Viele examine response-adaptive randomization (RAR) in clinical trials, dissecting its statistical rationale, commo...

REMAP-CAP: The Origin

REMAP-CAP: The Origin

Episode 65 · · 53:29

In this episode of "In the Interim…", Dr. Scott Berry explores the origins of REMAP-CAP with Prof. Steve Webb, former chair of the REMAP-CAP International Trial Steering Committee. T...

Fighting Time in Adaptive Trials

Fighting Time in Adaptive Trials

Episode 64 · · 56:09

In this episode of "In the Interim…", Dr. Scott Berry explores the challenge of protracted endpoint timelines in adaptive clinical trials and the statistical strategies used to incre...

ICECAP: The Adaptive Design

ICECAP: The Adaptive Design

Episode 63 · · 51:23

In this episode of "In the Interim…", Dr. Scott Berry is joined by Dr. Will Meurer, professor of Emergency Medicine and Neurology at the University of Michigan, for an in-depth discu...

Multi-Platform RCT

Multi-Platform RCT

Episode 62 · · 32:40

In this episode of "In the Interim…", Dr. Scott Berry details the design, execution, and results of the multi-platform randomized clinical trial (mpRCT) pioneered during the COVID-19...