Episodes

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A Visit with Andrew Thomson

A Visit with Andrew Thomson

Episode 33 · · 43:37

In this episode of "In the Interim…", Dr. Scott Berry interviews Dr. Andrew Thomson, owner and lead consultant of Regnitio. Thomson discusses his academic progression from mathematic...

Moving Clinical Trial Goalposts

Moving Clinical Trial Goalposts

Episode 32 · · 37:13

In this episode of "In the Interim…", Dr. Scott Berry and Dr. Kert Viele analyze how regulatory, editorial, and science community standards often impose additional, inconsistent requ...

The Not So Promising Zone Design

The Not So Promising Zone Design

Episode 31 · · 39:39

In this episode of "In the Interim…", Dr. Scott Berry examines the mathematical foundations and efficiency claims of the promising zone design for adaptive sample size in clinical tr...

A Visit with Dr. Janet Wittes

A Visit with Dr. Janet Wittes

Episode 30 · · 40:50

Episode 30 of “In the Interim…” features Dr. Janet Wittes, Fellow of the American Statistical Association, past president of the Society of Clinical Trials, and founder of Statistics...

Bayesian Clinical Trials with Frank Harrell

Bayesian Clinical Trials with Frank Harrell

Episode 29 · · 47:20

In this episode of "In the Interim…", Dr. Scott Berry chats with Frank Harrell, a professor of Biostatistics at Vanderbilt University and W.J. Dixon Award winner. Harrell describes h...

A Visit with Dr. Derek Angus

A Visit with Dr. Derek Angus

Episode 28 · · 41:58

In this episode of “In the Interim…”, Dr. Scott Berry interviews Dr. Derek Angus, Distinguished Professor and Chair of Critical Care Medicine at the University of Pittsburgh and Seni...

The Mystery of Clinical Trial Simulation

The Mystery of Clinical Trial Simulation

Episode 27 · · 41:38

Dr. Scott Berry hosts this episode of "In the Interim…", opening with statistical analysis of elite athletes before focusing on the misunderstood role of clinical trial simulation. H...

Discussions on the ICH E20 Draft Guidance

Discussions on the ICH E20 Draft Guidance

Episode 26 · · 38:17

In this episode of "In the Interim…", Dr. Scott Berry and Dr. Kert Viele review the ICH E20 draft guidance on adaptive clinical trial designs, offering a technical yet accessible bre...

A Discussion with Michael Proschan on Response-Adaptive Randomization

A Discussion with Michael Proschan on Response-Adaptive Randomization

Episode 25 · · 44:45

In this episode of "In the Interim…", Dr. Scott Berry and NIH’s Dr. Michael Proschan conduct a detailed discussion from opposing viewpoints on response-adaptive randomization (RAR) i...

STEP Statistical Modeling

STEP Statistical Modeling

Episode 24 · · 33:43

In this episode of "In the Interim…", Dr. Scott Berry, Dr. Elizabeth Lorenzi, and Dr. Amy Crawford discuss the STEP platform trial’s statistical methodology for evaluating which acut...

Bayesian Approach in Clinical Trials

Bayesian Approach in Clinical Trials

Episode 23 · · 43:43

This episode of "In the Interim…" features Dr. Scott Berry, Dr. Kert Viele, and Dr. Melanie Quintana of Berry Consultants dissecting the technical and operational landscape of Bayesi...

The Time Machine

The Time Machine

Episode 22 · · 39:08

Dr. Scott Berry and Dr. Kert Viele discuss the origins and implementation of the “time machine” modeling approach, beginning with sports analytics and progressing to adaptive platfor...

The Legend of I-SPY 2 - Part B

The Legend of I-SPY 2 - Part B

Episode 21 · · 25:45

In this episode, Dr. Don Berry and Dr. Scott Berry provide an in-depth account of I-SPY 2, focusing on the trial’s use of the “time machine” methodology—a Bayesian solution allowing ...

The Legend of I-SPY 2 - Part A

The Legend of I-SPY 2 - Part A

Episode 20 · · 40:09

In Episode 20 of Berry’s "In the Interim..." Podcast, The Legend of I-SPY 2 - Part A, Dr. Don Berry and Dr. Scott Berry discuss the origins and design of the I-SPY trials. Their conv...

The STEP Platform with Dr. Eva Mistry and Dr. Jordan Elm

The STEP Platform with Dr. Eva Mistry and Dr. Jordan Elm

Episode 19 · · 40:39

This episode of "In the Interim..." features an in-depth discussion of the StrokeNet Thrombectomy Endovascular Platform (STEP), a multi-domain, multi-factorial, adaptive platform tri...

A Statistician reads JAMA

A Statistician reads JAMA

Episode 18 · · 39:03

Dr. Scott Berry applies a statistician’s review of a random trial result published in JAMA – the FAIR-HF2 clinical trial.  Interrogating the frequentist paradigm and the focus on the...

Seamless 2/3 Trial Designs

Seamless 2/3 Trial Designs

Episode 17 · · 45:48

Scott Berry convenes co-authors Kert Viele, Joe Marion, and Lindsay Berry to discuss the statistical and developmental nuances of inferentially seamless phase 2/3 clinical trial desi...

Spending Alpha

Spending Alpha

Episode 16 · · 37:59

In this solo episode of "In the Interim...", Scott Berry, President and Senior Statistical Scientist at Berry Consultants, addresses deep-rooted confusion in the field of adaptive cl...

Prof Craig Ritchie: Looking Back at EPAD, moving forward in Alzheimer's Disease

Prof Craig Ritchie: Looking Back at EPAD, moving forward in Alzheimer's Disease

Episode 15 · · 37:17

Scott Berry, Founder of Berry Consultants, interviews Professor Craig Ritchie—specialist in brain health and neurodegenerative diseases, Chief Investigator of EPAD (European Preventi...

Drug Developers' Lessons from Sports: Regression-to-the-Mean

Drug Developers' Lessons from Sports: Regression-to-the-Mean

Episode 14 · · 41:09

In this engaging episode of "In the Interim...", host Dr. Scott Berry is joined by Dr. Nick Berry to explore the intriguing statistical parallels between sports and drug development,...